
Leuprolide Acetate
CAS No. 74381-53-6
Leuprolide Acetate ( Leuprorelin acetate )
产品货号. M19932 CAS No. 74381-53-6
Leuprolide 是垂体 GnRH 受体的激动剂。亮丙瑞林是一种促性腺激素释放激素 (GnRH) 类似物,用于治疗多种与性激素相关的疾病,包括晚期前列腺癌、子宫内膜异位症和性早熟。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥688 | 有现货 |
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10MG | ¥970 | 有现货 |
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50MG | ¥1614 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Leuprolide Acetate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Leuprolide 是垂体 GnRH 受体的激动剂。亮丙瑞林是一种促性腺激素释放激素 (GnRH) 类似物,用于治疗多种与性激素相关的疾病,包括晚期前列腺癌、子宫内膜异位症和性早熟。
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产品描述Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitization and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
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体外实验——
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体内实验——
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同义词Leuprorelin acetate
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通路Others
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靶点Other Targets
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受体GNRHR
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研究领域Cancer
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适应症Endometriosis
化学信息
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CAS Number74381-53-6
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分子量1269.45
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分子式C59H84N16O12. C2H4O2
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纯度>98% (HPLC)
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溶解度DMSO: 40 mg/mL;Water: 60 mg/mL
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SMILESCC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1
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化学全称Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wilson AC et al. Leuprolide acetate: a drug of diverse clinical applications. Expert Opin Investig Drugs. 2007 Nov;16(11):1851-63.
产品手册




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