Leuprolide Acetate ( Leuprorelin acetate )

产品货号. M19932 CAS No. 74381-53-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Leuprolide Acetate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Leuprolide 是垂体 GnRH 受体的激动剂。亮丙瑞林是一种促性腺激素释放激素 (GnRH) 类似物，用于治疗多种与性激素相关的疾病，包括晚期前列腺癌、子宫内膜异位症和性早熟。
产品描述

Leuprolide is an agonist at pituitary GnRH receptors. Leuprorelin is a gonadotropin-releasing hormone (GnRH) analog used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary inducing a transient early rise in gonadotrophin release. With continued use Leuprorelin causes pituitary desensitization and/or down-regulation leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of and thus desensitizing the GnRH receptors it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
体外实验

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体内实验

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同义词

Leuprorelin acetate
通路

Others
靶点

Other Targets
受体

GNRHR
研究领域

Cancer
适应症

Endometriosis

CAS Number

74381-53-6
分子量

1269.45
分子式

C59H84N16O12. C2H4O2
纯度

>98% (HPLC)
溶解度

DMSO: 40 mg/mL;Water: 60 mg/mL
SMILES

CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1
化学全称

Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate

1.Wilson AC et al. Leuprolide acetate: a drug of diverse clinical applications. Expert Opin Investig Drugs. 2007 Nov;16(11):1851-63.

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